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cilengitide tfa  (MedChemExpress)


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    MedChemExpress cilengitide tfa
    The partial reversal of the MFAP4-induced phenotype by pathway inhibitors. The fibrotic and apoptotic phenotypes induced by rMFAP4 incubation in LX-2 cells and by MFAP4 overexpression in LX-2 cells can be partially reversed by the integrin αvβ3 inhibitors <t>Cilengitide</t> (1 μM) ( A-D ) and Cyclo(-RGDfK) (2 μM) ( G-H ). Quantitative analysis of Western blotting is shown on the right . ∗Indicates a statistical significance between the rMFAP4 or OE-MFAP4 group and the DMSO or OE-Vector group; #Indicates statistical significance between the rMFAP4 or OE-MFAP4 group and the rMFAP4 + inhibitor group or OE-MFAP4 + inhibitor group. ∗∗ P < .01, ∗∗∗ P < .001. # P < .05, ## P < .01, ### P < .001.
    Cilengitide Tfa, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 57 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/cilengitide+tfa/Cilengitide/pmc12355556-262-2-5
    Average 95 stars, based on 57 article reviews
    cilengitide tfa - by Bioz Stars, 2026-08
    95/100 stars

    Images

    1) Product Images from "MFAP4 Deficiency Attenuates Liver Fibrosis by Regulating Hepatic Stellate Cell Fate Through Inhibition of the FAK/PI3K/NFκB Signaling Pathway"

    Article Title: MFAP4 Deficiency Attenuates Liver Fibrosis by Regulating Hepatic Stellate Cell Fate Through Inhibition of the FAK/PI3K/NFκB Signaling Pathway

    Journal: Cellular and Molecular Gastroenterology and Hepatology

    doi: 10.1016/j.jcmgh.2025.101548

    The partial reversal of the MFAP4-induced phenotype by pathway inhibitors. The fibrotic and apoptotic phenotypes induced by rMFAP4 incubation in LX-2 cells and by MFAP4 overexpression in LX-2 cells can be partially reversed by the integrin αvβ3 inhibitors Cilengitide (1 μM) ( A-D ) and Cyclo(-RGDfK) (2 μM) ( G-H ). Quantitative analysis of Western blotting is shown on the right . ∗Indicates a statistical significance between the rMFAP4 or OE-MFAP4 group and the DMSO or OE-Vector group; #Indicates statistical significance between the rMFAP4 or OE-MFAP4 group and the rMFAP4 + inhibitor group or OE-MFAP4 + inhibitor group. ∗∗ P < .01, ∗∗∗ P < .001. # P < .05, ## P < .01, ### P < .001.
    Figure Legend Snippet: The partial reversal of the MFAP4-induced phenotype by pathway inhibitors. The fibrotic and apoptotic phenotypes induced by rMFAP4 incubation in LX-2 cells and by MFAP4 overexpression in LX-2 cells can be partially reversed by the integrin αvβ3 inhibitors Cilengitide (1 μM) ( A-D ) and Cyclo(-RGDfK) (2 μM) ( G-H ). Quantitative analysis of Western blotting is shown on the right . ∗Indicates a statistical significance between the rMFAP4 or OE-MFAP4 group and the DMSO or OE-Vector group; #Indicates statistical significance between the rMFAP4 or OE-MFAP4 group and the rMFAP4 + inhibitor group or OE-MFAP4 + inhibitor group. ∗∗ P < .01, ∗∗∗ P < .001. # P < .05, ## P < .01, ### P < .001.

    Techniques Used: Incubation, Over Expression, Western Blot, Plasmid Preparation

    The relationship between MFAP4 and the activation of the FAK/PI3K/NFκB signaling pathway. ( A, B ) The integrin αvβ3 inhibitor Cilengitide (1 μM) partially reverses the activation of the FAK/PI3K/NFκB signaling pathway induced by rMFAP4 incubation or OE-MFAP4 in LX-2 cells. ( C, D ) Another integrin αvβ3 inhibitor, Cyclo(-RGDfK) (2 μM), partially reverses the activation of the FAK/PI3K/NFκB signaling pathway induced by rMFAP4 incubation or OE-MFAP4 in LX-2 cells. ( E, F ) The FAK-specific inhibitor Defactinib hydrochloride (10 μM) partially reverses the activation of the FAK/PI3K/NFκB signaling pathway induced by rMFAP4 incubation or OE-MFAP4 in LX-2 cells. Quantification of immunoblot results is shown on the right . ( G ) Immunofluorescence showing nuclear translocation of p-P65 in LX-2 cells after 24 hours of rMFAP4 incubation. Scale bars: 25 μm.
    Figure Legend Snippet: The relationship between MFAP4 and the activation of the FAK/PI3K/NFκB signaling pathway. ( A, B ) The integrin αvβ3 inhibitor Cilengitide (1 μM) partially reverses the activation of the FAK/PI3K/NFκB signaling pathway induced by rMFAP4 incubation or OE-MFAP4 in LX-2 cells. ( C, D ) Another integrin αvβ3 inhibitor, Cyclo(-RGDfK) (2 μM), partially reverses the activation of the FAK/PI3K/NFκB signaling pathway induced by rMFAP4 incubation or OE-MFAP4 in LX-2 cells. ( E, F ) The FAK-specific inhibitor Defactinib hydrochloride (10 μM) partially reverses the activation of the FAK/PI3K/NFκB signaling pathway induced by rMFAP4 incubation or OE-MFAP4 in LX-2 cells. Quantification of immunoblot results is shown on the right . ( G ) Immunofluorescence showing nuclear translocation of p-P65 in LX-2 cells after 24 hours of rMFAP4 incubation. Scale bars: 25 μm.

    Techniques Used: Activation Assay, Incubation, Western Blot, Immunofluorescence, Translocation Assay



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    The partial reversal of the MFAP4-induced phenotype by pathway inhibitors. The fibrotic and apoptotic phenotypes induced by rMFAP4 incubation in LX-2 cells and by MFAP4 overexpression in LX-2 cells can be partially reversed by the integrin αvβ3 inhibitors <t>Cilengitide</t> (1 μM) ( A-D ) and Cyclo(-RGDfK) (2 μM) ( G-H ). Quantitative analysis of Western blotting is shown on the right . ∗Indicates a statistical significance between the rMFAP4 or OE-MFAP4 group and the DMSO or OE-Vector group; #Indicates statistical significance between the rMFAP4 or OE-MFAP4 group and the rMFAP4 + inhibitor group or OE-MFAP4 + inhibitor group. ∗∗ P < .01, ∗∗∗ P < .001. # P < .05, ## P < .01, ### P < .001.
    Cilengitide Tfa, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/cilengitide+tfa/Cilengitide/pmc12355556-262-2-5
    Average 95 stars, based on 1 article reviews
    cilengitide tfa - by Bioz Stars, 2026-08
    95/100 stars
    		  Buy from Supplier

    Image Search Results


    The partial reversal of the MFAP4-induced phenotype by pathway inhibitors. The fibrotic and apoptotic phenotypes induced by rMFAP4 incubation in LX-2 cells and by MFAP4 overexpression in LX-2 cells can be partially reversed by the integrin αvβ3 inhibitors Cilengitide (1 μM) ( A-D ) and Cyclo(-RGDfK) (2 μM) ( G-H ). Quantitative analysis of Western blotting is shown on the right . ∗Indicates a statistical significance between the rMFAP4 or OE-MFAP4 group and the DMSO or OE-Vector group; #Indicates statistical significance between the rMFAP4 or OE-MFAP4 group and the rMFAP4 + inhibitor group or OE-MFAP4 + inhibitor group. ∗∗ P < .01, ∗∗∗ P < .001. # P < .05, ## P < .01, ### P < .001.

    Journal: Cellular and Molecular Gastroenterology and Hepatology

    Article Title: MFAP4 Deficiency Attenuates Liver Fibrosis by Regulating Hepatic Stellate Cell Fate Through Inhibition of the FAK/PI3K/NFκB Signaling Pathway

    doi: 10.1016/j.jcmgh.2025.101548

    Figure Lengend Snippet: The partial reversal of the MFAP4-induced phenotype by pathway inhibitors. The fibrotic and apoptotic phenotypes induced by rMFAP4 incubation in LX-2 cells and by MFAP4 overexpression in LX-2 cells can be partially reversed by the integrin αvβ3 inhibitors Cilengitide (1 μM) ( A-D ) and Cyclo(-RGDfK) (2 μM) ( G-H ). Quantitative analysis of Western blotting is shown on the right . ∗Indicates a statistical significance between the rMFAP4 or OE-MFAP4 group and the DMSO or OE-Vector group; #Indicates statistical significance between the rMFAP4 or OE-MFAP4 group and the rMFAP4 + inhibitor group or OE-MFAP4 + inhibitor group. ∗∗ P < .01, ∗∗∗ P < .001. # P < .05, ## P < .01, ### P < .001.

    Article Snippet: Integrin inhibitors: cilengitide TFA (HY-16143, MCE) and Cyclo(-RGDfK) TFA (HY-P0023A, MCE).

    Techniques: Incubation, Over Expression, Western Blot, Plasmid Preparation

    The relationship between MFAP4 and the activation of the FAK/PI3K/NFκB signaling pathway. ( A, B ) The integrin αvβ3 inhibitor Cilengitide (1 μM) partially reverses the activation of the FAK/PI3K/NFκB signaling pathway induced by rMFAP4 incubation or OE-MFAP4 in LX-2 cells. ( C, D ) Another integrin αvβ3 inhibitor, Cyclo(-RGDfK) (2 μM), partially reverses the activation of the FAK/PI3K/NFκB signaling pathway induced by rMFAP4 incubation or OE-MFAP4 in LX-2 cells. ( E, F ) The FAK-specific inhibitor Defactinib hydrochloride (10 μM) partially reverses the activation of the FAK/PI3K/NFκB signaling pathway induced by rMFAP4 incubation or OE-MFAP4 in LX-2 cells. Quantification of immunoblot results is shown on the right . ( G ) Immunofluorescence showing nuclear translocation of p-P65 in LX-2 cells after 24 hours of rMFAP4 incubation. Scale bars: 25 μm.

    Journal: Cellular and Molecular Gastroenterology and Hepatology

    Article Title: MFAP4 Deficiency Attenuates Liver Fibrosis by Regulating Hepatic Stellate Cell Fate Through Inhibition of the FAK/PI3K/NFκB Signaling Pathway

    doi: 10.1016/j.jcmgh.2025.101548

    Figure Lengend Snippet: The relationship between MFAP4 and the activation of the FAK/PI3K/NFκB signaling pathway. ( A, B ) The integrin αvβ3 inhibitor Cilengitide (1 μM) partially reverses the activation of the FAK/PI3K/NFκB signaling pathway induced by rMFAP4 incubation or OE-MFAP4 in LX-2 cells. ( C, D ) Another integrin αvβ3 inhibitor, Cyclo(-RGDfK) (2 μM), partially reverses the activation of the FAK/PI3K/NFκB signaling pathway induced by rMFAP4 incubation or OE-MFAP4 in LX-2 cells. ( E, F ) The FAK-specific inhibitor Defactinib hydrochloride (10 μM) partially reverses the activation of the FAK/PI3K/NFκB signaling pathway induced by rMFAP4 incubation or OE-MFAP4 in LX-2 cells. Quantification of immunoblot results is shown on the right . ( G ) Immunofluorescence showing nuclear translocation of p-P65 in LX-2 cells after 24 hours of rMFAP4 incubation. Scale bars: 25 μm.

    Article Snippet: Integrin inhibitors: cilengitide TFA (HY-16143, MCE) and Cyclo(-RGDfK) TFA (HY-P0023A, MCE).

    Techniques: Activation Assay, Incubation, Western Blot, Immunofluorescence, Translocation Assay